A practical synthesis of a (1→6)-linked β-d-glucosamine nonasaccharide Original Research Article

A (1→6)-β-d-glucosamine nonasaccharide was convergently synthesized using isopropyl thioglycosides as donors. Anomeric acetylated glucosamine derivatives were proved to be good acceptors in the NIS/TMSOTf catalyzed glycosylation. The target nonasaccharide showed a mild antitumor activity against H22 on the preliminary mice tests.