Enzymatic synthesis of d-glucosaminic acid from d-glucosamine

d-Glucosaminic acid (2-amino-2-deoxy-d-gluconic acid), a component of bacterial lipopolysaccharides and a chiral synthon, is easily prepared on a multigram scale by air oxidation of d-glucosamine (2-amino-2-deoxy-d-glucose) catalysed by glucose oxidase.