Title of article
β-d-Galactopyranosyl-thiohydroximates and d-galactopyranosylidene-spiro-oxathiazoles: synthesis and enzymatic evaluation against E. coli d-galactosidase
Author/Authors
Rita Elek، نويسنده , , Laszlo Kiss، نويسنده , , Jean-Pierre Praly، نويسنده , , L?szl? Soms?k، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2005
Pages
6
From page
1397
To page
1402
Abstract
By reaction with arylhydroximoyl chlorides, 2,3,4,6-tetra-O-acetyl-1-thio-β-d-galactopyranose was converted to the corresponding β-d-galactopyranosyl-thiohydroximates, which gave predominantly (1S)-d-galactopyranosylidene-spiro-oxathiazoles on illumination in the presence of NBS. Conventional O-deacetylation of both thiohydroximates and oxathiazoles gave weak inhibitors of E. coli d-galactosidase (Ki 1.1–11.1 mM).
Keywords
Spiro sugars , Galactosylidene-spiro-oxathiazoles , Galactosidase inhibitors , Galactosyl-thiohydroximates
Journal title
Carbohydrate Research
Serial Year
2005
Journal title
Carbohydrate Research
Record number
964428
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