Regioselective phosphorylation of branched cyclodextrins with cyclo-mono-μ-imidotriphosphate Original Research Article

The phosphorylation of the branched cyclodextrins, mono-6-O-(α-D-glucopyranosyl)cyclomaltohexaose, mono-6-O-(α-D-maltosyl)cyclomaltohexaose, mono-6-O-(α-D-glucopyranosyl)cyclomaltoheptaose, and mono-6-O-(α-D-maltosyl)cyclomaltoheptaose, in aqueous solution by sodium cyclo-mono-μ-imidotriphosphate (cMITP) was examined. In these reactions, only the 2-OH group of a single α-D-glucopyranosyl residue of the cyclodextrin ring was phosphorylated, in a maximum yield of 67%. A possible mechanism for the phosphorylation is discussed.