Title of article
Stereoselective synthesis of jaspine B from d-xylose Original Research Article
Author/Authors
Jun Liu، نويسنده , , Yuguo Du، نويسنده , , Xiaomin Dong، نويسنده , , Shucong Meng، نويسنده , , Junjun Xiao، نويسنده , , Lijian Cheng، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2006
Pages
5
From page
2653
To page
2657
Abstract
The natural cytotoxic marine compound, jaspine B, is stereoselectively synthesized from d-xylose in 11 linear steps with a 23.9% overall yield. The key step in the synthesis involves an iodine-induced debenzylation of a primary alcohol and the subsequent 2,5-cyclization to fit the required configuration of jaspine B. A preliminary bioassay shows strong inhibition activities against human MDA231, Hela, and CNE cell lines, indicating potential usage in various cancer treatments.
Keywords
Antitumor activity , Carbohydrates , Total synthesis , Natural products , Jaspine B
Journal title
Carbohydrate Research
Serial Year
2006
Journal title
Carbohydrate Research
Record number
965066
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