Title of article
A convenient preparation of 6-oligo(lactic acid)cyclomaltoheptaose as kinetically degradable derivative for controlled release of amoxicillin Original Research Article
Author/Authors
Jian Shen، نويسنده , , Aiyou Hao، نويسنده , , Guangyan Du، نويسنده , , Huacheng Zhang، نويسنده , , Hongyuan Sun، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2008
Pages
6
From page
2517
To page
2522
Abstract
6-Oligo(lactic acid)cyclomaltoheptaose (6-OLA-βCD) with an average substitution of about 7.0 lactic acid units was prepared as a new water-soluble cyclomaltoheptaose (βCD) derivative (solubility of about 70.7-fold that of βCD), based on the ring-opening polymerization of 3,6-dimethyl-1,4-dioxane-2,5-dione (lactide). The product was characterized by 1H NMR, 13C NMR, IR, and MS spectroscopy. The complexation of amoxicillin with 6-OLA-βCD was found to be much stronger than that with βCD at first, and then 6-OLA-βCD was shown to decompose moderately into βCD and lactic acid. 6-OLA-βCD might be greatly valuable in a controlled release system for Amoxicillin (AMX).
Keywords
?CD derivative , Drug carrier , Amoxicillin , Decomposition , 6-Oligo(lactic acid)-?CD
Journal title
Carbohydrate Research
Serial Year
2008
Journal title
Carbohydrate Research
Record number
965581
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