Title of article
The diastereoselective synthesis of methyl 5-deoxy-5-(dialkylphosphono)-5-(dialkylphosphorylamido)-2,3-O-isopropylidene-β-d-ribofuranosides Original Research Article
Author/Authors
Zhanwei Cui، نويسنده , , Jianfeng Zhang and Charles Dalton، نويسنده , , Fei Wang، نويسنده , , Yadan Wang، نويسنده , , Zhiwei Miao، نويسنده , , Ruyu Chen، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2008
Pages
5
From page
2530
To page
2534
Abstract
A convenient method has been developed for the diastereoselective synthesis of methyl 5-deoxy-5-(dialkylphosphono)-5-(dialkylphosphorylamido)-2,3-O-isopropylidene-β-d-ribofuranosides under mild conditions, namely the reaction of a dialkyl phosphoramidate with a dialkyl phosphite and methyl 2,3-O-isopropylidene-β-d-ribo-pentodialdo-1,4-furanoside in acetyl chloride in a one-pot procedure.
Keywords
Acetyl chloride , Diastereoselective synthesis , ?-Amino phosphonate , Mannich-type reaction
Journal title
Carbohydrate Research
Serial Year
2008
Journal title
Carbohydrate Research
Record number
965583
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