Author/Authors :
Claudia Sorbi، نويسنده , , Massimo Bergamin، نويسنده , , Susanna Bosi، نويسنده , , Francesca Dinon، نويسنده , , Vincent Aroulmoji، نويسنده , , Riaz Khan، نويسنده , , Erminio Murano، نويسنده , , Stefano Norbedo، نويسنده ,
Abstract :
Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
