Title of article
Synthesis of the C1-phosphonate analog of UDP-GlcNAc Original Research Article
Author/Authors
Robert Chang، نويسنده , , Thanh-Trang Vo، نويسنده , , Nathaniel S. Finney، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2006
Pages
7
From page
1998
To page
2004
Abstract
We describe the first synthesis of the C1-phosphonate analog of UDP-GlcNAc, based on a new preparation of the corresponding glycosyl phosphonate. This C-glycosyl analog is shown to be a very weak inhibitor (Ki > 10 mM) of fungal chitin synthase, indicating that at least in this case the replacement of the anomeric oxygen with a methylene group is not an innocent substitution.
Keywords
UDP-GlcNAc , Glycosyl phosphonate , Chitin synthase , Glycosyl transferase inhibition
Journal title
Carbohydrate Research
Serial Year
2006
Journal title
Carbohydrate Research
Record number
965825
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