Glycolipoprotein extract of Eisenia foetida (G-90): A source of biological active molecules

The G-90 is a macromolecular mixture with glycolipoprotein characteristics obtained from tissue homogenate of the earthworm Eisenia foetida. This macromolecular mixture exhibits numerous biological activities such as mitogenicity, anticoagulation, fibrinolysis, bacteriostasis and antioxidation in vitro and in vivo conditions. It is neither mutagenic nor cancerogenic. In our investigation G-90 did not contain the growth factors (FGF and EGF), but it stimulated their synthesis in cell cultures, which caused increased cell proliferation. It is likely that some pleiotropic activity of G-90 could be associated with the insulin-like proteins, tyrosine like serine peptidases and the immunoglobulin-like molecules. Some factors in G-90 recognised sera of patients with tumors, as well as those suffering from cardiopathies. Accordingly, G-90 is a valuable mixture of biologically active macromolecules, which could be very useful in human and veterinary medicine.