Title of article
Stereoselective synthesis of β-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis Original Research Article
Author/Authors
Benjamin Ayers، نويسنده , , Hilary Long، نويسنده , , Edith Sim، نويسنده , , Iain A. Smellie، نويسنده , , Brendan L. Wilkinson، نويسنده , , Antony J. Fairbanks، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2009
Pages
8
From page
739
To page
746
Abstract
A series of β-arabino glycosyl sulfones with varying alkyl chain lengths were synthesised in a stereoselective fashion as putative mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity with marked dependence on alkyl chain length, which was maximal for a C-12 chain.
Keywords
Mycobacteria , Tuberculosis , Carbohydrates , Glycosyl sulfones , Arabinose , Thioglycosides
Journal title
Carbohydrate Research
Serial Year
2009
Journal title
Carbohydrate Research
Record number
966371
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