Comparative solution and solid-phase glycosylations toward a disaccharide library Original Research Article

A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc–Glc, Glc–Gal, Gal–Glc, and Gal–Gal disaccharides was synthesized both in solution and on solid phase. The various reaction conditions for different approaches and corresponding yields are analyzed and discussed.