New cyclodextrin derivative 6-O-(2-hydroxybutyl)-β-cyclodextrin: preparation and its application in molecular binding and recognition Original Research Article

A new soluble cyclodextrin derivative 6-O-(2-hydroxybutyl)-β-cyclodextrin (6-HB-β-CD) was prepared. Its molecular binding and recognition ability were investigated with the comparison of β-cyclodextrin (β-CD), 2-O-(2-hydroxypropyl)-β-cyclodextrin (2-HP-β-CD), 6-O-(2-hydroxypropyl)-β-cyclodextrin (6-HP-β-CD), and 2-O-(2-hydroxybutyl)-β-cyclodextrin (2-HB-β-CD). The relationship between the complex stability constants and the possible structures of inclusion compounds was discussed with the interaction of hosts and guests, including the weak hydrophobic interactions, the size/shape matching, the steric hindrance, and the hydrophilic property.