Title of article :
Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by ‘click’ chemistry Original Research Article
Author/Authors :
L. Vijaya Raghava Reddy، نويسنده , , P. Venkat Reddy، نويسنده , , Nripendra N. Mishra، نويسنده , , Praveen K. Shukla، نويسنده , , Garima Yadav، نويسنده , , Ranjana Srivastava، نويسنده , , Arun K. Shaw، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2010
Abstract :
Thirteen new 1,2,3-triazoles (5a–e, 15a–d, 17a–b, 19, and 21) were synthesized by ‘click’ reaction of sugar-derived azides with commercially available acetylenes. The synthesized triazoles were tested in vitro for their biological activity, and compound 5b displayed both antibacterial and antifungal activities at an MIC value of 12.5 μg/mL, while compounds 15b and 19 showed antibacterial activity at an MIC value of 25 μg/mL.
Keywords :
2 , Click chemistry , 3-Triazoles , THF domain , 1
Journal title :
Carbohydrate Research
Journal title :
Carbohydrate Research
