Author/Authors :
Laura Russo، نويسنده , , Elena Landi، نويسنده , , Anna Tampieri، نويسنده , , Antonino Natalello، نويسنده , , Silvia M. Doglia، نويسنده , , Luca Gabrielli، نويسنده , , Laura Cipolla، نويسنده , , Francesco Nicotra، نويسنده ,
Abstract :
An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The ‘glycosylated’ hydroxypatite was characterised by its ability to interact with glucose recognising lectins.
Keywords :
Hydroxyapatite , Click chemistry , Propargyl glycosides , Biomaterials , Lectin
