Title of article
A facile synthesis of d-ribo-C20-phytosphingosine and its C2 epimer from d-ribose Original Research Article
Author/Authors
Miroslava Martinkov?، نويسنده , , Jozef Gonda، نويسنده , , Kvetoslava Pomikalov?، نويسنده , , Jozef Ko???ek، نويسنده , , Juraj Kuch?r، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2011
Pages
11
From page
1728
To page
1738
Abstract
A facile synthetic route to d-ribo-C20-phytosphingosine 31 and its C2 epimer 32 is described. The Overman rearrangement of allylic trichloroacetimidates derived from the known ribose derivative 7 has been used as the key step. The subsequent functional group interconversions in rearranged products 14 and 15 followed by Wittig olefination, Pd/C-mediated reduction and the removal of protecting groups successfully constructed the final molecules.
Keywords
Sphingolipids , Phytosphingosine , Overman rearrangement , Trichloroacetamides
Journal title
Carbohydrate Research
Serial Year
2011
Journal title
Carbohydrate Research
Record number
967238
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