Author/Authors :
Ming-Li Zhao، نويسنده , , Jia-en Zhang، نويسنده , , Jie Gao، نويسنده , , Zhao Zhang، نويسنده , , Yu-Tao Zhao، نويسنده , , Wen Qu، نويسنده , , Hongmin Liu، نويسنده ,
Abstract :
A formal synthesis of Jaspine B was completed in 42.4% overall yield with only three purification steps (one by crystallization and two by column chromatography). The key step in the synthesis involves a regio- and stereoselective epoxide ring-opening reaction and the configuration inversion of the C3-hydroxyl group through oxidation and reduction. All of the reagents and materials used were quite common and inexpensive.
