Author/Authors :
Deveer، Rüya نويسنده Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey , , Deveer، Mehmet نويسنده Department of Radiology, Sitki Kocman University Scool of Medicine, Mugla, Turkey , , Engin-Ustün، Yaprak نويسنده Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey , , Akbaba، Eren نويسنده Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey , , Uysal، Sema نويسنده Departmen of Biochemistry, Fatih University Scool of Medicine, Ankara, Turkey , , Sarikaya، Esma نويسنده Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey , , Gülerman، Cavidan نويسنده Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey , , Mollamahmutoglu، Leyla نويسنده Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey ,
Abstract :
Background: Reactive oxygen species (ROS) are produced in many metabolic and physiologic
processes. Antioxidative mechanisms remove these harmful species. Our aim was
to assess whether serum total antioxidant capacity and total oxidant status altered during
first trimester pregnancies with vaginal bleeding.
Materials and Methods: In this cross-sectional study, A group of pregnant women at less
than 10 weeks of gestation with vaginal bleeding (n=25) and a control group of healthy
pregnancies with similar characteristics (n=25) were included. All of the patients in the two
groups were matched for age, gestational age and body mass index. Serum total antioxidant
capacity and total oxidant status levels were determined using a Hitachi 912 analyzer and
compared between the two groups.
Results: Characteristics, including maternal age, parity, and gestational age were similar
between the two groups. Serum total antioxidant capacity levels were significantly lower
in the women with vaginal bleeding than in control women (1.16 ± 0.20 vs. 1.77 ± 0.08
mmol Trolox Equiv./L; p=0.001), whereas higher total oxidant status measurements were
found in women with vaginal bleeding compared to the control group (4.01 ± 0.20 vs.
2.57 ± 0.65 ?mol H2O2 Equiv./L; p=0.001).
Conclusion: Increased total oxidant status might be involved in the pathophysiology of
vaginal bleeding during early first trimester pregnancies.
