Interaction of organic derivatives of tin IV/ and lead IV/ with model lipid membranes

Here we present the results of a comparative study on the interactions between the trialkyl-, triphenyl derivatives of tin IV. and lead IV. and dialkyl-, diphenyltin IV. derivatives on the planar bilayer lipid membranes BLMs., widely applied as a model of cell membrane. The relative degree of depolarization of the lipid membrane potential caused by the influence of the above compounds was applied as a parameter to estimate their toxicity. The research has shown, that trialkyl derivatives of tin IV. are considered as the most active ones in relation to BLM from all alkyl tin and lead derivatives that have been studied. Dialkyltin IV. and trialkyllead IV. derivatives were found to be the least active. In phenyl derivatives group, the activity sequence is as follow: triphenyllead)triphenyltin) diphenyltin. Depolarization activity of compounds investigated strongly depended on the lipophilicity of their reaction with water products.