The effect of personal factors on the relationship between carbon disulfide exposure and urinary 2-thiothiazolidine-4-carboxylic acid levels in rayon manufacturing workers

Background: Few studies have been conducted to explore how personal factors—personal hygiene, personal protective equipment, and skin exposure affect the exposure-dose relationship in workers exposed to carbon disulfide (CS2). Methods: Personal environmental monitoring of airborne CS2 and 2-thiothiazolidine-4-carboxylic acid (TTCA) levels in post-shift urine were determined for sixty-five rayon workers. The personal factors affecting the CS2-TTCA relationship were measured by questionnaire and dermatological diagnosis. Results: In simple linear regression analyses, we found shower right after work, respirator, gloves, apron, and skin disease were significantly associated with U-TTCA levels among all personal factors. Skin disease was, however, the only personal factor that remained significant throughout multivariate linear regression analyses. Conclusions: In this study, the personal factor like hostʹs skin disease was found to possibly affect the relations of U-TTCA to the occupational exposure to CS2. The skin exposure to CS2 for those who have skin problems on the sites possibly or potentially exposed to CS2 in the occupational environment such as in the rayon manufacturing process is noteworthy. Workers with susceptible skins should either be assigned to work in areas without contacting hazardous materials directly or required to wear appropriately protective clothing.