Title of article :
The non-steroidal anti-inflammatory drug diclofenac is readily biodegradable in agricultural soils Original Research Article
Author/Authors :
Abdul Jabbar Al-Rajab، نويسنده , , Lyne Sabourin، نويسنده , , David R. Lapen، نويسنده , , Edward Topp ، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2010
Abstract :
Diclofenac, 2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid, is an important non-steroidal anti-inflammatory drug widely used for human and animals to reduce inflammation and pain. Diclofenac could potentially reach agricultural lands through the application of municipal biosolids or wastewater, and in the absence of any environmental fate data, we evaluated its persistence in agricultural soils incubated in the laboratory. 14C-Diclofenac was rapidly mineralized without a lag when added to soils varying widely in texture (sandy loam, loam, clay loam). Over a range of temperature and moisture conditions extractable 14C-diclofenac residues decreased with half lives < 5 days. No extractable transformation products were detectable by HPLC. Diclofenac mineralization in the loam soil was abolished by heat sterilization. Addition of biosolids to sterile or non-sterile soil did not accelerate the dissipation of diclofenac. These findings indicate that diclofenac is readily biodegradable in agricultural soils.
Keywords :
Diclofenac sodium , Dissipation , Pharmaceutical , Soil , Biosolids , Biodegradation
Journal title :
Science of the Total Environment
Journal title :
Science of the Total Environment