Cancer is one of the deadly and dangerous diseases that, on average, annually causes the death of six million people, so attention to prevention and treatment is of particular importance. Microalgae are a large group of simple organisms and autotrophs. Due to the wide range of secondary metabolites, they are considered as rich and valuable medicinal compounds with various therapeutic properties.The aim of this project was to measure the antitumor activity of Methanolic Extract, Ethyl Ester and N-hexane in macroalgae species (including Sargassum sp., Padina sp.) Isolated from the Persian Gulf coast in Qeshm Island, against, colon, breast and liver cancer cells. Cancer cells, Colon, breasts, liver were incubated in RPMI1640 enriched with 10% FBS, incubated at 37 ° C and 5% CO2. The effects of 3 concentrations (0.1, 0.5 and 1mg / ml) of methanolic and ethylistate extracts and hexane extracts on the biological ability of cancer cells were evaluated using MTT colorimetric method.The results showed that two brown seaweed Padina sp. an‎d Sargassum sp. have high cytotoxic activity against cancer cell lines. Anticancerous effects with IC50 to 81.42 μg / ml in hexane extracts against liver cancer cells as well as 295/8 μg / ml in methanolic extracts against cancer cells Breast and 204.5 μg / ml in the Diethyl ether extract of studied algae showed that the macroalgae extracts of studied species can be considered in subsequent studies as a source of anticancer compounds against cancer cells of the liver, breast and Colon. These results proved that due to the lower cytotoxic effects of metabolites extracts against normal cells relative to cancer cells, these metabolites can be candidates for subsequent studies.

تركيبات طبيعي , ماكروجلبك هاي قهوه اي , سيتوتوكسيك , خليج فارس و درياي عمان

تهران موسسه تحقيقات علوم شيلاتي كشور

مصور، جدول، نمودار، نقشه

موسسه تحقيقات علوم شيلاتي كشور 54838