عنوان به زبان ديگر :
Endothelium-Dependent Attenuating Effect of Trigonella foenumgraecum on the Contractile Vascular Reactivity of Diabetic Rats
پديد آورندگان :
Vaez Mahdavi Mohammad Reza نويسنده , Roghan Mehrdad نويسنده , Baluchnejadmojarad Tourandokht نويسنده
چكيده لاتين :
The present study was undertaken to determine whether two-month treatment of streptozotocin (STZ)-diabetic rats with aqueous leaf extract of Trigonella foenum-graecum (TFG; 200 mg/kg; i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. For this purpose, vascular responses to KCI and noradrenaline (NA) were measured. Diabetic state significantly increased contractile responses to KCI and NA in aortic rings in both endothelium-intact and -denuded rings. Extract-treated diabetic rats showed a significant lower maximal contractile response to KCI only in endothelium-intact rings as compared to diabetic rings. It is concluded that intraperitoneal administration of aqueous leaf extract of TFG for two months could improve some functional indices of the vascular system in diabetic state and the integrity of the endothelium is essential for its beneficial effects.
