پديد آورندگان :
Rezaieyazdi Z نويسنده , Sandooghi M نويسنده , Mansouri Torghabe H نويسنده , Derhami A نويسنده
چكيده لاتين :
Multicentric reticulohistiocytosis (MRH) is a rare proliferative histiocytic disease of
unknown cause with potentially disabling nature. Primary manifestations are involvement of skin and
joints. The articular destruction can lead to permanent joint deformities. Our patient was a 47 year-old
woman with bilateral symmetrical polyarthritis and reddish- brown papulonodular cutaneous lesions.
The diagnosis of multicentric reticulohistiocytosis was confirmed by histological examination. Both
skin and articular manifestations were only partially treated with oral corticosteroids, monthly bolus
cyclophosphamide, weekly methotrexate and knee synoviorthesis with nitrogen mustard.
