چكيده لاتين :
Cystoscopy and urinary cytology are currently the basis for diagnosis and follow-up of
bladder tUlnors. Research to find a sensitive and specific tunlor TIlarker for diagnosis of bladder tunlor is
actively underway, however, due to low sensitivity and high cost of cytology. This cross-sectional study
was performed in 65 patients to evaluate \vhether urinary bladder cancer (lJBC) antigen level can
predict the presence of active bladder tumor. In patients with inactive tumor, LfBC antigen level was
detennined in addition to standard cystoscopy and cytology for follow-up. Patients with active tumor
were subjected to standard treatment and LfBC antigen level determination. lJBC antigen levels were
measured by ELISA, using nl0noclonal antibodies specific for UBC antigen. As a control group, UBC
antigen level was also detennined in 65 persons who had been referred for urinalysis for other reasons.
UBC antigen level more than 1 J.lg/L which was regarded as positive was found in 49.4~) of the
patients. In control group, 96.9°~ had UBC antigen < 1J.lg/L. Mean UBC antigen level in patients was
3.77 J.lg/L while it was 0.508 J.lg/L in controls (P < 0.0001). Sensitivity of UBC antigen was 53.3~/o and
its specificity was 40°A>. Sensitivity and specificity of urinary cytology was 17 .3~/o and 88.20/0,
respectively. This difference was statistically significant (P < 0.001). UBC antigen is 1110re sensitive
than urinary cytology, although cytology still retains its priority in specificity. It is not yet
recommended to replace lJBC antigen for cytology due to its low specificity and not favorable sensitivity
