پديد آورندگان :
lravani M نويسنده , Mohebbi B نويسنده , Alimoghadam K نويسنده , Moosavi A نويسنده , Najar-Najafi S نويسنده , Ardalan A نويسنده , Ghavamzadeh A نويسنده
چكيده لاتين :
Interleukin-10 (lL-10) is a potent immunosuppressor which inhibits alloantigenic T cell
response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive
significance of endogenous IL-1 0 for acute graft versus host disease (GVHD) following allogeneic bone
marrow transplantation (BMT), we performed a prospective study on spontaneous IL-10 production in
the senlm of 96 patients admitted for allogeneic BMT. High spontaneous IL-1 0 production at the time
of admission and prior to any preparative treatment correlates with a subsequent low incidence of
G\THD as compared to patients with low IL-IO production. Our data demonstrate the predictive
significance of increased IL-10 production in BMT patients and suggest a role for it in maintaining
immunobalance in the setting of allogenic BMT.
