چكيده لاتين :
Background and purpose of the study: Several polymeric systems have been used to
fabricate ocular inserts for better ocular bioavailability and retention to drug of which
gelling systems have shown advantages of convenient administration and increased contact
time. The purpose of the present study was to develop a bioadhesive in-situe gelling ocular
insert of Gatifloxacin using polymeric system of sodium alginate as gelling and chitosan as
bioadhesive agent.
Materials and methods: Polymeric ocular inserts of Gatifloxacin sesquehydrate (GS) were
composed using sodium alginate and chitosan with glycerin as plasticizer by solvent casting
method. The ocular inserts were investigated for physicochemical properties (thickness,
weight variation, folding endurance and surface pH), mechanical strength (tensile strength,
elongation at break), swelling index, and bioadhesion parameters. In vitro release studies
were carried using a fabricated donor-receptor compartment model.
Results: Cumulative drug released from the formulation ranged from 95-99% within 8-12h.
The formulation D (2% sodium alginate and 1 % chitosan) sustained the drug release for the
longest period of time (12h). Zero-order release of the drug was from optimized
formulation D. A high correlation coefficient (r=0.9845) was recorded between in vitro and
in vivo drug release.
Conclusion: Gatifloxacin sesquehydrate inserts have appreciable film forming properties
and were found to posses good antimicrobial efficacy.
