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A New Synthesis of 1,3-Aminols from Direct Double Reduction of p-Enamino Ketones Formed in situ by Reaction of p-Dicarbonyl Compounds with Anilines

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A new one-pot synthesis of 1,3-aminols by direct reduction of (3-enamino ketones, formed in situ by reaction of easily available (3-dicarbonyl compounds, with anilines were described. In the case of aliphatic amines such as benzyl amine, n-butyl amine and (3-hydroxy ethyl amine, the corresponding 1,3-minols were not obtained. In fact, the p-enamino ketone formed was failed to accomplish further reduction to 1,3-aminol. This approach is the most direct available method for the synthesis of 1,3-aminols

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