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Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study

Shakibaei Fereshteh نويسنده , Gholamrezaei Ali نويسنده , Heidari Shahram نويسنده

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BACKGROUND: Sleep bruxism is a common sleep disorder with unclear etiology and no definitive treatment. Recent suggested medications are not often practically used due to their numerous limitations. Based on the fact that sleep bruxism occurs most often in the second stage of non-REM sleep, this study aimed to assess the effect of trazodone on sleep bruxism. METHODS; This pilot study was conducted as a before-after design on 28 children and adolescents with 6-18 years of age SUffering from sleep bruxism referring by children and adolescents mental health clinic, children dental specialists and pediatricians. The treatment started with 0.5mg/kg/day. In non-responders, it was weekly added by 0.5 mg/kg/day (with optimum of2 mg/kg/day). Frequency of bruxism and related morning face/jaw pain were assessed daily from two weeks before (baseline) to four weeks after starting the intervention by the parents/roommate. RESULTS; Findings showed a significant reduction in the frequency of both bruxism and related morning pain from baseline to the 2nd and the 4th weeks of the intervention (P