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The effects of sodium arsenite on the testis structure and sex hormones in vasectomised rats

Soleimani Mehranjani Malek نويسنده , Hemadi Masood نويسنده

127

133

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Background: Sodium arsenite and! or vasectomy may cause variation in sex hormones which affect pathophysiology of reproductive organs. Objective: The aim was to investigate the morphological changes in structure of testis and hormonal imbalance in bilateral Vasectomised rats treated with sodium arsenite. Materials and Methods: Four groups of rats: bilateral vasectomy + sodium arsenite, bilateral vasectomy, sham operated + sodium arsenite and sham operated only were considered, and 8 mglkg! day of sodium arsenite was given for 8 weeks to the rats. The total volume of testis, volume of interstitial tissue, volume of seminiferous tubules, diameter of seminiferous tubules and germinal epithelium thickness were evaluated using stereological methods. Hormones were also measured and the results were analyzed using one way ANOVA. Results: A significant reduction of total volume of testis (p