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Sensitivity and Specificity of Procalcitonin in Diagnosis of Neonatal Sepsis

Mahmoudzadeh Mahdi نويسنده , Kheiri Soleyman نويسنده , Irnani Reza نويسنده , Shahabi Ghorbanali نويسنده , Saedi Ebrahim نويسنده , Taheri Elham نويسنده , Motamedi Reihaneh نويسنده , Khoshdel Abolfazal نويسنده

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Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests, This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NICU and neonatal ward in Shahrekord Hajar hospital were enrolled. A full workup including blood cultureand other tests and PCT was conductede. Sensitivity, specificity, positive and negative predictive values for PCT was determined. Results: It was found out that 8 patients had definite infection, 15 patients had possible infection,and 127 patients had no infection. Although PCT was not able to significantly differentiate between those with definite and possible infections (p>0.05), but there· was a significant difference for frequency of abnormal PCT between non-infectious patients and other patients. Sensitivity, specificity, positive and negative predictive values of PCT was 87.5%, 87.4%, 30.4 (Yo , 99.1%, and 87.41% respectively. Conclusion: Beside the limitation of the sample size, the satisfactory diagnostic characteristics of PCT highlight it as a good measure for diagnosis of neonatal sepsis. Further studies are essential to be carried out.

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