چكيده لاتين :
BACKGROUND: Chamomile is a beneficial herbal drug that is used as an anti-inflammatory, sedative and anti-allergic
agent. The mechanism of action of matricaria recutita (MR), a specious of chamomile, in nociception in male and female
animals is not fully understood. In this study, the sedative effect of a species of chamomile, MR, on acute pain was
investigated in both male and female adult mice in the presence and absence of sex hormones.
METHODS: Male and female NMRI mice weighing 28 ± 3 grams were used. Animals of each sex were divided into intact
and gonadectomized groups. Intact group received saline or MR extract (10, 30, 50 mg/kg, intraperitoneally). Gonadectomized
group contained two subgroups: a) group that received saline or MR hydro alcoholic extract (50 mg/kg,
I.P.), and b) group that received sex hormones (testosterone in male mice and estradiol benzoate and progesterone in
female mice), both with and without MR extract (50mg/kg, IP). The analgesia times in all groups were evaluated by hot
plate test.
ItESULTS: MR increased analgesia time both in intact and gonadectomized male and female mice, but had no effect in
the presence of pharmacological doses of testosterone (2 mg/kg, subcutaneous) in male mice, and estradiol benzoate
(0.1 mg/kg, SC) and progesterone (0.5 mg/kg, SC) in female mice.
