پديد آورندگان :
Rasekh Hamid Reza نويسنده , Yazdanpanah Hasan نويسنده , Hosseinzadeh Leila نويسنده , Bazmohammadi Narges نويسنده , Kamalinejad Mohammad نويسنده
چكيده لاتين :
Teucrium Polium L. (TP) is widely used in traditional medicine of many countries including
Iran . There are various reports about pharmacological properties of TP such as calcium
antagonist, anti- ulcer, ant i - diabeti c. There are a few reports about possible toxicological
effects of this plant. In the present study we designed to evaluate the subchronic toxicity of
Teucrium Polium total extract in rats.
Sprague Dawley rats (40 males, 40 females) were divided into four dose groups
(10 animals/dose/sex ) and were gavaged daily with either 100, 300 or 600 mg/kg of the
total extract for 44 days . Control group was received normal saline . Body weight and food
consumption was monitored daily. After 45 days animal was sacr ificed and hematological and
biochemical parameters, as well as weight of left kidney and liver were measured .
There was no significant difference in hematological param eters in both sexes as compared
to their respecti ve Controls. In bioch emical parameters, a significant increase (p<0.05) was
seen in both ALT and AST enzyme activities in female rats receiving 300 mg/kg TP. There
was also a significant increase in liver weight of male rats receiving 600 mg/kg. No other
significant changes in any other parameter were observed.
Present data sugge sts that female rats are more sensitive to higher doses of TP and
that liver could serve as a target organ toxicity of this extract.
