پديد آورندگان :
Ashrafi Mahnaz نويسنده , Salman Yazdi Reza نويسنده , Madani Tahereh نويسنده , Bazrafshan Alireza نويسنده
چكيده لاتين :
Background: Approximately 2-4% of all women have recurrent spontan eous abortion
(RSA); however, the cause is determined in only 50% ofcases . Recent studies have shown an
association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion .
The aim of the present study was to determine whether circulating anti-thyroid peroxidase
(anti-TPO) was associated with RSA.
Materials and Methods: In this observ ational analyt ic study, Sera from 58 non-pregnant
women with a history of RSA and also 58 healthy, fertile subjects with at least one live birth
as control (Aging from 18 to 45 years) were tested for thyroid peroxidase antibodies by
means of a standard Anti-TPO ELISA kit. We used data collection forms and SPSS software
for data analysis .
Results: Of 116women , 8 (13.8%) ofthe control subjects and 12 (20.7%) ofthe women with
a history of RSA had positive results for anti-TPO. There was not any significant association
between presence of anti-TPO and RSA.
Conclusions: We did not find any correlation between the presence ofTPO antibodies and
abortion in women with a history of RSA. On the basis of this study, testing for anti-TPO
doesn יt seem to be useful in the evaluation of patients with a history of RSA.
