چكيده لاتين :
Trichomonas vaginalis infection is a sexually transmitted infection causing vaginitis and acute inflammatory disease of the
genital mucosa. Although Metronidazole resistance in T. vaginalis is well documented, The only drug approved for the
treatment of trichomoniasis in some countries is metronidazole. Genus Allium plants including garlic; shallot and onion
have had an important medicinal role for centuries. Some study have proven antibacterial, antifungal, antiviral, antiprotozoal
and antihelmintic properties of genus Allium plants. at first PSHE and PSDE ( persian shallot hydroalcoholic and
dichlromethanic extract) was prepared in ethanol/water (50:50) and dichlromethane respectively at cool temperature (10؛C).
genus Allium plants extracts were shown to decrease the oxygen uptake, reduce the growth of the organism, inhibit the synthesis
of lipids, proteins and nucleic acids and damage membranes. In this study the Minimal Inhibitory Concentrations
(MICs) of PSHE, PSDE and metronidazole respectively were 10, 5 and 2µg/ml. Persian shallot inhibited growth of T.
vaginalis at low concentrations and in short times, therefore this plant have some antitrichomonas components (including
allicin, ajoene and other organosulfides) that antimicrobial properties of these was proven.
