پديد آورندگان :
Ashrafi Mahnaz نويسنده , Zafarani Fatemeh نويسنده , Shahrokh Tehrani Nejad Ensieh نويسنده , Amirchaghmaghi Elham نويسنده
چكيده لاتين :
Background:
With aging, the ovarian reserve is decreased and that is a major contributor to poor
ovarian response to exogenous gonadotropins. The aim of the present study is to evaluate the role
of Dexamethasone on ovarian response in infertile patients aged over 35 years undergoing IYFI
rcsr cycles.
Materials and Methods: In this triple blind placbo-control clinical trial study, a total of 72
infertile women over age 35, undergoing IYF/ICSI cycles, referred to Royan Institute from May
2000 to May 2002 were selected. Dexamethasone co-treatment (Img/d) was started on the 21st of
their preceding menstrual cycle and it was continued until oocyte aspiration. The main outcome
measures were number ofretrieved oocytes, number offertilized and transferred embryos, number
of used HMO, serum E2 level on HCO injection day, and pregnancy rate .
Results: There was no significant statistical difference in age, duration of infertility, Body mass
index, hormonal tests, number of retrieved oocytes and transferred embryos. However, the
number of used HMO was significantly lower in Dexamethasone group compared to placebo
group (30.6± 13.39 versus 41.64 ± 18.34) (p<0.05).
Conclusion: The addition of dexamethasone lrng/d to standard long protocol decreased the
number ofHMO used in patients over 35 years who hold known risk of low ovarian response.
