عنوان به زبان ديگر :
Synthesis of some New Thiosemicarbazide and 1,3,4-Thiadiazole Heterocycles Bearing Benzo[b]Thiophene Nucleus as a Potent Antitubercular and Antimicrobial Agents.
پديد آورندگان :
Vasoya S. L. نويسنده , Paghdar D. J. نويسنده , Chovatia P. T. نويسنده , Joshi H. S. نويسنده
چكيده لاتين :
Reaction of 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo[b] thiophene with different substituted phenyl isothiocyanate gave N-substituted arylthiosemi-carbazide derivatives (1a-h). 1,3,4-Thiadiazole derivatives (2a-h) were prepared by the cyclization of arylthiosemicarbazides (1a-h) with concentrated sulphuric acid. All the compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv) and antimicrobial activity against various microorganisms.
