17156

Solid Lithium Perchlorate, a Highly Efficient and Chemoselective Catalyst for the Acetalyzation of Aldehydes.

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A simple, efficient, and general method has been developed for the chemoselective acetalization of aldehydes with 1,3-propanediol, 1,2-ethanediol and trimethyl orthoformate in the presence of solid lithium perchlorate under solvent-free conditions. Both cyclic and acyclic acetals of aldehydes were obtained under environmentally benign conditions in good to excellent yields.

1201078