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Acute Combined Demyelination of CNS and PNS: A Case Report

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Acute disseminated encephalomyelitis (ADEM) and Guillain-Barre syndrome (GBS) are both para infectious demyelinatinq disorders. While ADEM almost always affects the CNS, GBS affects the PNS. The combined demyelinatinq process - demyelination of both upper motor neuron (UMN) and lower motor neuron (LMN) - occurs very rarely. Here we report a case of severe combined peripheral and central demyelination, in which the former disorder was preceded by the latter.

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