پديد آورندگان :
SHAMS JAMAL نويسنده , SAHRAEI HEDAYAT نويسنده , FAGHIH MONZAVI ZOHREH نويسنده , SALIMI SEYED HOSSEIN نويسنده , FATEMI SEYEDEH MAEDEH نويسنده , POURMATABBED ALI نويسنده , GHOSHOONI HASSAN نويسنده , Kamalinejad Mohammad نويسنده
چكيده لاتين :
Previous studies have shown that the extract of Papaver rhoeas reduces morphine
dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol
extract ofPapaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been
investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5
and 10 mg/kg) induced analgesia. However, intrapretoneal administration of the hydro-alcohol
extract ofPapaver rhoeas (25, 50 and 100 mg/kg) had not an effects on analgesia. Reduction of
analgesic in mice pretreated with morphine (50 mg/kg, twice daily; for 3 days), alone, indicated
that tolerance has been developed. Hydro-alcohol extract of Papaver rhoeas (25,50 and 100
mg/kg, i.p.) administration, 30 min before each of three daily doses of morphine, attenuated
the morphine tolerance dose-independently, indicating that administration ofthe extract reduces
morphine tolerance in mice.
