چكيده لاتين :
T the importance of type 2 Diabetes mellitus
as a risk factor for osteoporosis in
postmenopausal women.
Materials and Methods: This study was
conducted in 2004 on 40 diabetic and 40 healthy
postmenopausal women attending the endocrine
clinics in Zanjan. These two groups were
matched in terms of age, length of their menopausal
period and body mass index. Serum calcium,
phosphorus, alkaline phosphatase and estradiol
were measured in all cases and bone densities
at three sites (Femoral neck, lumbar spine
and forearm) were evaluated with dual X-ray absorptiometry
(OXA). All data were analyzed using
t-test, analysis of variance, chi-square and
multiple regression tests.
Results: The frequency of osteoporosis and osteopenia
in diabetic women were not significantly
different from non-diabetics. The mean
bone density in the femoral neck was higher in
the diabetic group (0.806±0.13 grjcm2 vs 0.726 ±
0.15 grjcm2), (p: 0.002). In the diabetic group
there was a negative correlation between bone
density and length of menopause in the femoral
neck (r:-o.49, p:0.004), lumbar spine (r:-0.58, p:
0.005) and mid radius (r:-0.37, p: 0.03). The relationship
between BMI and bone density was
significant in the femoral neck (r: 0.55, p: 0.01) in
diabetic women. In diabetic women, the higher
the HbAlc the lower the bone density in lumbar
sp ine.
Conclusion: Although the level of HbAlc as a
Correspondence: Faranak Sharifi, Internal Medicine
Ward , Vali - Asr Hospital, Zanjan, Iran
E-mail : FaranakSharifi @hotmail. com
Conclusion: Although the level of HbAlc as a
marker of blood glucose control has a relationship
with lumbar spine density in diabetics, diabetes
type 2 is not a risk factor for osteoporosis.
Hence measures should be taken individually
similar to non diabetic patients, for screening,
diagnosis and management of osteoporosis in
diabetes type 2.
