مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

Today, although screening tests for Gestational Diabetes Mellitus (GDM) are available, they are time-consuming and expensive; hence performing tests that are cheaper but have higher sensitivity and specificity seems necessary. The aim of this study was to determine a cut off point of fasting plasma glucose (FPG) for screening GDM. Materials and Methods: In this clinical trial, 200 pregnant women aged > = 25 years referring to a perinatal clinic were selected Inclusion criteria required having one of the following risk factors: History of recurrent abortion, GDM, pre-eclampsia, macrosomia, still birth, or diabetes mellitus(DM) in first degree family or pre gestational body mass index > = 25kg/m2. All participants underwent a 50 g glucose challenge test (GCT) between the 24th and 28th gestational week. If יl-hour plasma glucose was over 130 mgldL, a 3-hour 100g oral glucose tolerance test (OGIT) was recommended. The diagnosis of GDM was made based on ADA recommendations. Results: Of 200 participants, 65 women had positive GCT, of which 58 (response rate 89%) were referred for 100g OGIT and 20 (10%) were diagnosed with GDM. The under curve area for FPG of 0.85 and the FPG level of 91.5 mgldL, showed highest sensitivity -80%, and specificity -92%, respectively in the diagnosis of GDM. Significant difference was observed between the GDM and normal groups for mean age, gravidity, parity and BMI (P<0.05). Conclusion: Fasting plasma glucose (FPG) > 91.5 mgldL has good sensitivity and specificity in the screening of GDM; since this is simpler and cheaper than the 50g GCT, it is recommended as a screening method for the diagnosis of GDM.