چكيده لاتين :
Idiopathic hypercalciuria is a leading cause of frequency-dysuria syndrome in childhood.
Different modes of inheritance have been suggested in this disease. This article presents the occurrence
of idiopathic hypercalciuria in all children of two families. In the first family, a 5.5 year old girl with a
history of renal stones and dysuria due to bypercalciuria, had two involved brothers and one sister. In
the second family, bypercalciuria and medullary nephrocalcinosis were detected in two siblings who
were admitted for polyuria and dysuria. Idiopathic type of hypercalciuria was diagnosed in these two
families by normal laboratory exams and exclusion of other causes of nonnocalcemic hypercalciuria.
According to the involvement of all offsprings (both sexes) in these two families, it is suggested that
idiopathic hypcrcalciuria is an autosomal dominant disease with complete penetration.
Acta Medica Iranica, 44(5): 357-369; 2006
© 2006 Tehran University of Medical Sciences. All rights reserved.
