پديد آورندگان :
Khosravi Farideh نويسنده , Jarnshidr Ahmad Reza نويسنده , Amirkhanl Aref نويسنده , Ansartpour Bita نويسنده , Pourpak Zahra نويسنده , Moin Mostafa نويسنده , Nikbin Behrooz نويسنده , Nlcknam Mohamad Hossein نويسنده , Mahmoud Mahdi نويسنده , Amirzargar Ali Akbar نويسنده , Ganjalikhani Hakemi Mazdak نويسنده
چكيده لاتين :
The human leukocyte antigen-B27 is one of the class I molecules of the major
histocompatibility complex which is strongly associated with ankylosing spondylitis (AS).
The strength of the disease association with B27 varies markedly among racial and ethnic
populations. It is an allele family, which constitutes about 31 subtypes, with a considerable
geographic and ethnic difference in distribution. It is important to know whether certain
subtypes show any preferential association with AS. Because there is no report regarding
HLA-B27 subtypes in Iranian patients with AS, the main purpose of the present study was
to assess the frequency of subtypes of human leukocyte antigen (HLA)-B27 in patients with
ankylosing spondylitis in Iranian population
One hundred and nineteen AS patients (82 HLA-B27 positive and 37 HLA-B27 negative)
were selected for this study. HLA-B27 positive patients were screened by polymerase chain
reaction amplification with sequence-specific primers (pCR-SSP) for B*27 subtyping.
The results of present study revealed that only two subtypes were detected in Iranian
patients, including B*2705 (52 patients, 63.4%) and B*2702 (30 patients, 36.6%).
Our resu lts showed a restricted number of HLA-B27 subtypes associated with AS in
Iran and an elevated frequency of the B*2705 allele in these patients similar to other EuroCaucasoid
(Aryan) groups in the world.
