عنوان به زبان ديگر :
Genetic Diversity in the Circumsporozoite Protein Gene of Plasmodiumfalciparum from Major Endemic Regions of Iran
پديد آورندگان :
Heidarl A. نويسنده , Keshavarz M. H. نويسنده , Assmar M. نويسنده , Razavi M. نويسنده , Nateghpour M. نويسنده , Dittrich Petra S. نويسنده , Jelinek T . نويسنده
چكيده لاتين :
Circumsporozoite protein (CSP) is one of the stage specific antigens, which is used for the development of vaccines and to
investigate the genetic diversity in Plasmodium jalciparum malaria parasite. Polymerase chain reaction was used for typing
of CSP genes on 67 positive jalciparum malaria patients from Sistan and Baluchistan Province of Iran. Three fragments
were detected for CSP gene. Twenty, 38 and 4 samples showed 700, 750 and 800 bp fragments, respectively. Sequences of
some samples were aligned and compared with P.falciparum csp gene in gene bank. While the falciparum malaria endemic
region of Iran is classified in low to moderate group but, extensive polymorphism was observed in the samples that could be
taken into account in designing malaria vaccine.
