چكيده لاتين :
Celiac disease (CD) has been reported in association with genetic disorders such as Down’s
syndrome and Turner’s syndrome (TS). This study was undertaken to assess the prevalence of CD
among a group of patients with TS. Forty eight girls with TS and a control group composed by 48
healthy unrelated girls were screened for CD by IgA antiendomysial antibody (IgA-EMA). Total IgA of
serum was measured in all of the patients and controls and EMA was measured in subjects who had
normal range of IgA. Endoscopy and biopsy of duodenum was performed for EMA positive patients
and pathologic evaluation was done according to Marsh’s classification. Total IgA of serum in all of the
subjects was in normal range. Two subjects, both with TS, were EMA positive, resulting in a prevalence
of 4.1% in TS. Duodenal biopsy was performed in these patients and histologic changes of samples
were classified as grade II in one and grade II b in another one. Results of this study are compatible
with previous observations placing girls with TS at higher risk for CD relative to general population and
justifying screening of CD in patients with TS.
