چكيده لاتين :
Zinc sulphate is currently used for treatment ofzinc deficiency. Its uptake by the body is poor,
necessitating the administration of high doses. This leads to a range of unpleasant side effects.
In order to increase the bioavailability of zinc, several zinc complexes have been designed
and synthesized using bidentate ligands of hydroxypyranones and hydroxypyridinones.
Elemental analysis in each zinc complex was consistent with the formulations of ZnL2 species
L: bidentate ligand) with 1.5 or 7 water molecules per zinc and the water molecules were
removed by heating in a vacuum oven to yield anhydrous zinc complexes.
The partition coefficients (~art)of the complexes were also determined in l-octanoll
buffer (at pH 7.40) system by using shake-flask method. It was found that, the complexes
with hydroxypyranone ligands possess higher ~art values than those with hydroxypyidinone
ligands. Therefore, the comparison of the complexes highlights the hydroxypyranone zinc
complexes as the most promising candidates for using in zinc deficiency. Since it was
anticipated that this type of complexes probably possesses suitable lipophilicity to facilitate
their penetration into the gastrointestinal tract.
