مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and Y-maze performance in male diabetic rats. For this purpose, male Wistar rats were randomly divided into control and diabetic groups. For induction of diabetes, streptozotocin (STZ) was injected i.p, at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of I", 2nd , and 3rd months using passive avoidance and V-maze tasks. It was found out that mean IL exhibits a significant increase only at the end of 2Dd (p<0.05) and 3r d (p<0.01) months. In addition, STL significantly reduced at the end of r d (p<0.05) and 3r d months (p<0.01). Regarding V-maze task, alternation score of the diabetic rats was lower than that of the control ones at the end of 1י1 (p<0.05), 2nd (p<0.01), and 3r d (p<0.01) months as compared to time-matched control group. To conclude, at least one month is strictly required for development of behavioral disturbances in passive avoidance and V-maze tasks in STZ-diabetic rats. Iran. Biomed. 1. 10 (2): 99-104, 2006