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Studies on the Charge-Transfer Interaction Between Tamoxifen Citrate and Chloranilic Acid

Brown Sinyeofori A. نويسنده , Akpabio Ekaete I. نويسنده , Akpa Paul A. نويسنده , Nnamani Petra O. نويسنده , Akabuogu Bertrand C. نويسنده , Onunkwo Godswill C. نويسنده

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Abstract The complex formed as a consequence of the interaction between the electronacceptor P-chloranilic acid and an electron donor tamoxifen citrate was employed in the assay of the drug in pure powder and tablets. Chloranilic acid was found to form a charge-transfer complex in a 1:1 stoichiometric ratio, with tamoxifen citrate. The wavelength of maximum absorption for the complex was found to be 550 nm while the absorbance was linear over the concentration range of 2-100 g/ml. Evaluations of the various thermodynamic parameters by means of the Scott equation was carried out and were found to decrease with increase in temperature. The free energy change (L1GO) and the enthalpy of formation (L1HO) as well as the entropy (L1S 0) were determined for various interactions. Results obtained suggest that the proposed method may be conveniently applied in the analysi s of commercially available.tamoxifen citrate tablets with a high degree of accuracy and reproducibility.

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