مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

A series of novel indeno[l, 2-b]quinoxalin-ll-ylidenamines 2-9 have been synthesized via condensation of indane[l, 2-b]quinoxalin-ll-one (1) with various primary aromatic amines in presence of AcOH for 3 h. Compound 1 was synthesized by condensation of indane-1 ,2,3-trione with benzene-1,2-diamine in presence of AcOH. The synthesized compounds were characterized by IR, IH-NMR;י mass spectra and elemental analysis. Compounds 2-9 were screened for anti-nociceptive, anti-inflammatory and antiepileptic activity by AcOH induced writhing method, carrageenan induced paw edema method and maximal electroshock induced convulsion method respectively. Out of the eight synthesized compounds, indeno[l, 2-b ]quinoxalin-ll-ylidine (4-nitrophenyl)amine (3) exhibited promising antiinflammatory activity and anti-nociceptive activity. N-(2,4-dinitrophenyl)-Nי -(indeno[l,2-b]quinoxalin-ll-ylidene)hydrazine (7) showed promising anti inflammatory activity, anti-nociceptive activity, and antiepileptic activity, whereas N4-indeno[1, 2-b]quinoxalin-ll -ylidene biphenyl-4,4י-diarnine (8) showed promising anti-inflammatory activity.